Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 14/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19905475 | 0.92 | PRKDC (0.46) | PRKDCFAAHSLC40A1ABL1BCR | |
| SCHEMBL19355625 | 0.92 | PRKDC (0.44) | PRKDCFAAHSLC40A1 | |
| SCHEMBL19355626 | 0.92 | PRKDC (0.44) | PRKDCFAAHSLC40A1 | |
| SCHEMBL15339623 | 0.92 | PRKDC (0.55) | PRKDCFAAHSLC40A1ABL1BCR | |
| SCHEMBL19905399 | 0.92 | PRKDC (0.55) | PRKDCFAAHSLC40A1 | |
| SCHEMBL20373201 | 0.91 | PRKDC (0.47) | PRKDCFAAHSLC40A1 | |
| SCHEMBL19355506 | 0.91 | PRKDC (0.46) | PRKDCFAAHSLC40A1 | |
| SCHEMBL19905083 | 0.90 | PRKDC (0.44) | PRKDCFAAHSLC40A1LMNATP53 | |
| SCHEMBL22838610 | 0.90 | PRKDC (0.45) | PRKDCFAAHSLC40A1ABL1BCR | |
| SCHEMBL19905125 | 0.90 | PRKDC (0.46) | PRKDCFAAHSLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |