SCHEMBL19905232

SCHEMBL19905232

CNC(=O)c1ccc(CCNc2cc(-c3ccc(C)nc3)ncn2)c(OC)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK4 Q9HAZ1 11/20 0.46
CYP1A2 P05177 11/20 0.46
CYP3A4 P08684 10/20 0.46
CYP2D6 P10635 9/20 0.46
USP2 O75604 5/20 0.46
CYP2C19 P33261 8/20 0.45
HSD17B10 Q99714 6/20 0.43
TSHR P16473 5/20 0.43
ALDH1A1 P00352 7/20 0.42
ALOX15 P16050 5/20 0.42
ROCK2 O75116 1/20 0.41
ROCK1 Q13464 1/20 0.41
LMNA P02545 2/20 0.41
ABL1 P00519 4/20 0.40
BCR P11274 4/20 0.40
NAMPT P43490 1/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
GLA P06280 1/20 0.39
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15356521 0.91 CYP1A2 (0.47) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL19355397 0.89 CYP1A2 (0.44) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL16660255 0.89 CYP1A2 (0.49) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL19355070 0.88 CLK4 (0.42) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL19355388 0.88 CYP1A2 (0.44) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL19355269 0.87 CYP1A2 (0.42) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL19905107 0.86 CYP1A2 (0.47) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL20373455 0.86 CYP1A2 (0.42) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL19355457 0.86 HIF1A (0.43) CLK4CYP1A2CYP3A4CYP2D6USP2
SCHEMBL19355069 0.86 CYP1A2 (0.42) CLK4CYP1A2CYP3A4CYP2D6USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3057959-B1 DNA-PK INHIBITORS VERTEX PHARMA (US) 2018-02-28 EP disclosed