Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 16/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17874697 | 1.00 | PRKDC (0.44) | PRKDCFAAHABL1BCRKDR | |
| SCHEMBL17634922 | 0.92 | PRKDC (0.46) | PRKDCFAAHABL1BCR | |
| SCHEMBL17874736 | 0.90 | PRKDC (0.45) | PRKDCFAAHABL1BCR | |
| SCHEMBL15339625 | 0.89 | PRKDC (0.55) | PRKDCFAAHABL1BCR | |
| SCHEMBL15339667 | 0.89 | PRKDC (0.48) | PRKDCFAAHABL1BCR | |
| SCHEMBL17874692 | 0.89 | PRKDC (0.46) | PRKDCFAAH | |
| SCHEMBL15473127 | 0.88 | PRKDC (0.43) | PRKDCFAAHABL1BCR | |
| SCHEMBL17874737 | 0.88 | PRKDC (0.45) | PRKDCFAAH | |
| SCHEMBL17874718 | 0.88 | PRKDC (0.43) | PRKDCFAAHABL1BCR | |
| SCHEMBL16665021 | 0.88 | PRKDC (0.45) | PRKDCFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |