Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.39 |
| ▸ | BCR | P11274 | 6/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 5/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17634758 | 0.92 | PRKDC (0.46) | ABL1BCRPRKDCFAAHSLC40A1 | |
| SCHEMBL19355283 | 0.88 | PRKDC (0.41) | ABL1BCRPRKDCFAAHSLC40A1 | |
| SCHEMBL20373542 | 0.87 | PRKDC (0.40) | ABL1BCRPRKDCFAAHSLC40A1 | |
| SCHEMBL19355572 | 0.87 | PRKDC (0.40) | ABL1BCRPRKDCFAAHSLC40A1 | |
| SCHEMBL20373149 | 0.86 | PRKDC (0.38) | ABL1BCRPRKDCFAAHSLC40A1 | |
| SCHEMBL19355279 | 0.86 | PRKDC (0.43) | ABL1BCRPRKDCFAAHSLC40A1 | |
| SCHEMBL20373549 | 0.86 | PRKDC (0.44) | ABL1BCRPRKDCFAAHSLC40A1 | |
| SCHEMBL19355288 | 0.86 | CYP1A2 (0.43) | ABL1BCRFAAHSLC40A1USP2 | |
| SCHEMBL20373509 | 0.86 | PRKDC (0.45) | PRKDCFAAHSLC40A1LRRK2USP2 | |
| SCHEMBL19355516 | 0.85 | PRKDC (0.39) | PRKDCFAAHSLC40A1LRRK2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |