Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | EDNRB | P24530 | 8/20 | 0.42 |
| ▸ | EDNRA | P25101 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601015 | 0.90 | ALK (0.57) | ALKPOLBEDNRBEDNRAMEN1 | |
| SCHEMBL1601542 | 0.90 | ALK (0.66) | ALKEDNRBEDNRAMAP4K4 | |
| SCHEMBL19908483 | 0.84 | ALK (0.51) | ALKPOLBEDNRBEDNRAMEN1 | |
| SCHEMBL1602024 | 0.84 | ALK (0.51) | ALKPOLBEDNRBEDNRAMEN1 | |
| SCHEMBL1601737 | 0.83 | ALK (0.61) | ALKEDNRBEDNRAALDH1A1PDGFRB | |
| SCHEMBL1600967 | 0.80 | GSK3A (0.48) | ALKGSK3AGSK3BALDH1A1 | |
| SCHEMBL3602326 | 0.80 | GSK3A (0.48) | ALKPOLBKMT2AGSK3AGSK3B | |
| SCHEMBL1600131 | 0.79 | ALK (0.67) | ALKALDH1A1MET | |
| SCHEMBL1601054 | 0.79 | ALK (0.47) | ALKMEN1KMT2AGSK3AGSK3B | |
| SCHEMBL1602137 | 0.78 | ALK (0.52) | ALKEDNRBEDNRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |