Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600367 | 0.84 | ALK (0.51) | ALKKDR | |
| SCHEMBL1601054 | 0.83 | ALK (0.47) | ALKGSK3AGSK3BBRD4 | |
| SCHEMBL1600967 | 0.82 | GSK3A (0.48) | ALKGSK3AGSK3BBRD4 | |
| SCHEMBL3602326 | 0.80 | GSK3A (0.48) | ALKGSK3AGSK3BBRD4CHEK1 | |
| SCHEMBL1601519 | 0.80 | ALK (0.73) | ALKHRH3 | |
| SCHEMBL19908284 | 0.80 | ALK (0.47) | ALKGSK3AGSK3BBRD4CHEK1 | |
| SCHEMBL14387472 | 0.79 | GSK3A (0.47) | ALKGSK3AGSK3BBRD4 | |
| SCHEMBL1602401 | 0.79 | ALK (0.47) | ALKGSK3AGSK3BBRD4CHEK1 | |
| SCHEMBL1601032 | 0.79 | NEK1 (0.48) | ALKGSK3AGSK3BBRD4 | |
| SCHEMBL1601399 | 0.79 | ALK (0.53) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |