Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.93 |
| ▸ | MET | P08581 | 3/20 | 0.75 |
| ▸ | JAK2 | O60674 | 2/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.75 |
| ▸ | ABL1 | P00519 | 2/20 | 0.75 |
| ▸ | LCK | P06239 | 2/20 | 0.75 |
| ▸ | CSF1R | P07333 | 2/20 | 0.75 |
| ▸ | RET | P07949 | 2/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.75 |
| ▸ | LTK | P29376 | 2/20 | 0.75 |
| ▸ | FLT3 | P36888 | 2/20 | 0.75 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.75 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.75 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.75 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.75 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.75 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.75 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601968 | 0.97 | ALK (1.00) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1601647 | 0.92 | ALK (0.84) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1601065 | 0.86 | ALK (1.00) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1601552 | 0.86 | ALK (0.80) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1366338 | 0.82 | ALK (0.74) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1600853 | 0.82 | ALK (0.73) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1600012 | 0.81 | ALK (1.00) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1601136 | 0.81 | ALK (0.73) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1601297 | 0.80 | ALK (1.00) | ALKMETJAK2PRKD3MAP4K4 | |
| SCHEMBL1601648 | 0.80 | ALK (0.70) | ALKMETJAK2PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |