Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 1.00 |
| ▸ | MET | P08581 | 11/20 | 0.60 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1602249 | 1.00 | ALK (1.00) | ALKMETCSF1RHRH3 | |
| SCHEMBL19908286 | 0.90 | ALK (0.82) | ALKMETHRH3 | |
| SCHEMBL1601607 | 0.90 | ALK (0.82) | ALKMETHRH3 | |
| SCHEMBL1602264 | 0.88 | ALK (0.79) | ALKMETHRH3 | |
| SCHEMBL1600989 | 0.88 | ALK (1.00) | ALKMETCSF1R | |
| SCHEMBL12062631 | 0.88 | ALK (0.78) | ALKMETCSF1R | |
| SCHEMBL12052420 | 0.88 | ALK (1.00) | ALKMETCSF1R | |
| SCHEMBL1600993 | 0.87 | ALK (0.88) | ALKMETHRH3 | |
| SCHEMBL1600991 | 0.87 | ALK (0.88) | ALKMETHRH3 | |
| SCHEMBL1601751 | 0.84 | ALK (1.00) | ALKMETHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |