Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27824291 | 0.88 | KDM4E (0.67) | KDM4EATMHTR2ATSHRTAAR1 | |
| SCHEMBL1972068 | 0.83 | ATM (0.73) | KDM4EATMTSHRTAAR1MAPK1 | |
| Hydrochloric Acid SCHEMBL10440706 | 0.82 | ATM (0.71) | KDM4EATMTSHRTAAR1MAPK1 | |
| SCHEMBL2255231 | 0.82 | ATM (0.47) | KDM4EATMHTR2ATSHRTAAR1 | |
| SCHEMBL1023837 | 0.81 | ATM (0.76) | KDM4EATMTSHRTAAR1MAPK1 | |
| SCHEMBL2468726 | 0.76 | ATM (0.79) | KDM4EATMTSHRTAAR1MAPK1 | |
| SCHEMBL6567763 | 0.76 | TNKS2 (0.47) | KDM4EHTR2ATUBB4ATUBBTUBA3C | |
| SCHEMBL11851678 | 0.76 | TAAR1 (0.78) | KDM4EATMTSHRTAAR1MAPK1 | |
| SCHEMBL28461973 | 0.76 | TAAR1 (0.78) | KDM4EATMTSHRTAAR1MAPK1 | |
| SCHEMBL28733753 | 0.75 | KDM4E (0.56) | KDM4EATMTSHRTAAR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287441-B1 | ACYLATED 4-AMINOPIPERIDINES AS INHIBITORS OF SERINE PALMITOYLTRANSFERASE | TAKEDA PHARMACEUTICALS CO (JP) | 2021-06-09 | — | — | EP | disclosed |
| EP-3287441-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2018-02-28 | — | — | EP | disclosed |