SCHEMBL19908980

SCHEMBL19908980

Cc1ccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(-c3ccncc3)cc(-n3c4ccc(-c5ccc(C)cc5)cc4c4cc(-c5cc(-c6ccc7c8ccccc8n(-c8cc(-c9ccncc9)cc(-n9c%10ccccc%10c%10ccc(-c%11ccc(C)c(-c%12ccc(-c%13ccc%14c(c%13)c%13cc(-c%15cccc(C)c%15)ccc%13n%14-c%13cc(-c%14ccncc%14)cc(-n%14c%15ccc(-c%16ccccc%16)cc%15c%15cc(-c%16cccc(C)c%16)ccc%15%14)c%13C#N)cc%12C)c%11)cc%109)c8C#N)c7c6)ccc5C)ccc43)c2C#N)cc1

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33
PIP4K2A P48426 1/20 0.32
PIK3R2 O00459 1/20 0.32
SQOR Q9Y6N5 1/20 0.31
KDM4A O75164 1/20 0.31
KDM5B Q9UGL1 1/20 0.31
PDE9A O76083 1/20 0.31
PDE1C Q14123 1/20 0.31
FLT3 P36888 1/20 0.30
MAPK14 Q16539 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21414278 0.91 ADORA2A (0.30) ADORA2AADORA1PDE9APDE1C
SCHEMBL21546849 0.91 ELANE (0.31) ADORA2AADORA1PDE9APDE1C
SCHEMBL22562578 0.90 ADORA1 (0.38) ADORA2AADORA1PIP4K2AKDM4AKDM5B
SCHEMBL19909194 0.89 ADORA2A (0.38) ADORA2AADORA1KDM4AKDM5B
SCHEMBL19942682 0.88 ADORA2A (0.33) ADORA2AADORA1KDM4AKDM5B
SCHEMBL19903562 0.88 AR (0.32)
SCHEMBL22563498 0.87 ADORA2A (0.37) ADORA2AADORA1KDM4AKDM5B
SCHEMBL19919788 0.86 ABL1 (0.33) PIK3R2SQORPDE9APDE1CFLT3
SCHEMBL20617082 0.86 AR (0.31)
SCHEMBL22170345 0.85 PDE1C (0.35) ADORA2AADORA1PIP4K2ASQORKDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3287451-A1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2018-02-28 EP disclosed