Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.53 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | MLLT1 | Q03111 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CD38 | P28907 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16038484 | 0.78 | SMYD3 (0.56) | SMYD3GRM5ANO1NPC1RAB9A | |
| SCHEMBL25592912 | 0.78 | SMYD3 (0.56) | SMYD3GRM5KDRUSP30ANO1 | |
| SCHEMBL15820978 | 0.76 | SMYD3 (0.53) | SMYD3GRM5KDRUSP30ANO1 | |
| SCHEMBL244445 | 0.76 | SMYD3 (0.67) | SMYD3GRM5KDRUSP30ANO1 | |
| SCHEMBL25692506 | 0.75 | SMYD3 (0.55) | SMYD3GRM5KDRUSP30NPC1 | |
| SCHEMBL244667 | 0.75 | SMYD3 (0.66) | SMYD3GRM5KDRANO1 | |
| SCHEMBL18755890 | 0.74 | GRM5 (0.56) | SMYD3GRM5KDRMLLT1ANO1 | |
| SCHEMBL2442535 | 0.74 | SMYD3 (0.51) | SMYD3GRM5KDRMLLT1USP30 | |
| SCHEMBL4938486 | 0.74 | SMYD3 (0.57) | SMYD3GRM5KDRRAB9ACD38 | |
| SCHEMBL2442538 | 0.74 | SMYD3 (0.51) | SMYD3GRM5KDRUSP30ANO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935248-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-02-28 | — | — | EP | disclosed |