Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | CDK14 | O94921 | 1/20 | 0.35 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16078787 | 0.84 | POLB (0.45) | — | |
| SCHEMBL18285080 | 0.84 | JAK3 (0.38) | JAK3BTKEGFRCDK14CCNY | |
| SCHEMBL18285079 | 0.84 | JAK3 (0.38) | JAK3BTKEGFRCDK14CCNY | |
| SCHEMBL24244462 | 0.84 | MAPT (0.41) | JAK3EGFRCDK14CCNY | |
| SCHEMBL30072903 | 0.84 | JAK3 (0.41) | JAK3EGFR | |
| SCHEMBL18455437 | 0.84 | JAK3 (0.41) | JAK3EGFR | |
| SCHEMBL30046361 | 0.82 | JAK3 (0.41) | JAK3EGFR | |
| SCHEMBL17150911 | 0.82 | JAK3 (0.41) | JAK3EGFR | |
| SCHEMBL19190232 | 0.82 | JAK3 (0.41) | JAK3EGFR | |
| SCHEMBL24337533 | 0.81 | GPR183 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842433-B1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | MEDSHINE DISCOVERY INC (CN) | 2023-11-01 | — | — | EP | disclosed |
| EP-3741756-B1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | MEDSHINE DISCOVERY INC (CN) | 2023-11-01 | — | — | EP | disclosed |
| EP-3842433-A1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | Medshine Discovery Inc. (CN) | 2021-06-30 | — | — | EP | disclosed |
| WO-2021023247-A1 | KRAS MUTANT PROTEIN INHIBITOR | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2021-02-11 | — | — | WO | disclosed |
| EP-3741756-A1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | Medshine Discovery Inc. (CN) | 2020-11-25 | — | — | EP | disclosed |
| WO-2019141250-A1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | 南京明德新药研发股份有限公司 | 2019-07-25 | — | — | WO | disclosed |
| EP-2970163-B1 | 5-THIAZOLECARBOXAMIDE DERVATIVES AND THEIR USE AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-02-28 | — | — | EP | disclosed |