Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 16/20 | 0.76 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.60 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.60 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.60 |
| ▸ | DLK1 | P80370 | 1/20 | 0.56 |
| ▸ | DRG1 | Q9Y295 | 1/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19910090 | 0.90 | MAP3K12 (0.88) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL19910108 | 0.89 | MAP3K12 (0.73) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL16568301 | 0.89 | MAP3K12 (0.73) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL15602637 | 0.89 | MAP3K12 (0.70) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL19910078 | 0.88 | MAP3K12 (0.69) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL15602404 | 0.88 | MAP3K12 (0.86) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL15602459 | 0.87 | MAP3K12 (0.73) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL15602438 | 0.87 | MAP3K12 (1.00) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL15602605 | 0.86 | MAP3K12 (0.78) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 | |
| SCHEMBL16573745 | 0.86 | MAP3K12 (0.67) | MAP3K12MAP3K13MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852584-B1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |