Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 20/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19899304 | 0.85 | HTRA1 (0.51) | HTRA1 | |
| SCHEMBL21104809 | 0.85 | HTRA1 (0.51) | HTRA1 | |
| SCHEMBL19899306 | 0.85 | HTRA1 (0.51) | HTRA1 | |
| Hydrochloric Acid SCHEMBL21059296 | 0.84 | HTRA1 (0.51) | HTRA1 | |
| Hydrochloric Acid SCHEMBL21059293 | 0.84 | HTRA1 (0.51) | HTRA1 | |
| SCHEMBL21098814 | 0.83 | HTRA1 (0.58) | HTRA1 | |
| SCHEMBL19899378 | 0.81 | HTRA1 (0.44) | HTRA1 | |
| SCHEMBL19899379 | 0.81 | HTRA1 (0.44) | HTRA1 | |
| Hydrochloric Acid SCHEMBL21057067 | 0.81 | HTRA1 (0.44) | HTRA1 | |
| SCHEMBL19912824 | 0.81 | HTRA1 (0.42) | HTRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504197-B1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-11-17 | — | — | EP | disclosed |
| WO-2018036957-A1 | NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-01 | — | — | WO | disclosed |