Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 20/20 | 0.81 |
| ▸ | HTR2A | P28223 | 19/20 | 0.81 |
| ▸ | HTR2B | P41595 | 17/20 | 0.81 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1094137 | 0.89 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1094135 | 0.89 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1096477 | 0.89 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL19914899 | 0.79 | HTR2C (0.81) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1095131 | 0.78 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1095130 | 0.78 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL1096101 | 0.78 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL15996756 | 0.76 | HTR2C (0.68) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL12151155 | 0.76 | HTR2C (0.68) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| SCHEMBL9285425 | 0.75 | HTR2C (0.60) | HTR2CHTR2AHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374796-B1 | 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its salts, solvates or hydrates and its use for the treatment of CNS disorderes | ARENA PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |