Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.46 |
| ▸ | MELK | Q14680 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19911117 | 0.86 | NR1H2 (0.51) | NR1H2DDR1KDM4EALDH1A1ATM | |
| SCHEMBL19911119 | 0.84 | NR1H2 (0.53) | NR1H2RETFLT3MKNK1MKNK2 | |
| SCHEMBL9609582 | 0.84 | NR1H2 (0.68) | NR1H2DDR1ABL1KDM4EALDH1A1 | |
| SCHEMBL15237068 | 0.83 | PDE3B (0.50) | NR1H2KDM4EALDH1A1ATMTSHR | |
| SCHEMBL9609583 | 0.83 | MLNR (0.48) | NR1H2TACR1ABL1ALDH1A1TSHR | |
| SCHEMBL17320454 | 0.83 | NR1H2 (0.51) | NR1H2DDR1MELKCSF1RYES1 | |
| SCHEMBL25531032 | 0.82 | NR1H2 (0.48) | NR1H2KDM4EALDH1A1ATMPOLB | |
| SCHEMBL9609585 | 0.82 | NR1H2 (0.54) | NR1H2DDR1ABL1KDM4EALDH1A1 | |
| SCHEMBL20706218 | 0.82 | DDR1 (0.42) | NR1H2DDR1MELKCSF1RYES1 | |
| SCHEMBL1782464 | 0.81 | GPR183 (0.52) | NR1H2DDR1MELKMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10196378-B2 | Inhibitors of BCR-ABL mutants and use thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-02-05 | — | — | US | disclosed |
| US-20180057479-A1 | Inhibitors of BCR-ABL Mutants and Use Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057479-A1 | Inhibitors of BCR-ABL Mutants and Use Thereof | ABL1, BCR, ABL2 | NR1H2 3982/4885DDR1 1969/4885MELK 708/4885 |
| US-10196378-B2 | Inhibitors of BCR-ABL mutants and use thereof | ABL1, BCR, ABL2 | NR1H2 3982/4885DDR1 1969/4885MELK 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.