Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 6/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.48 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15424143 | 0.86 | HDAC1 (0.53) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL27122926 | 0.83 | HDAC1 (0.80) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL30702323 | 0.83 | HDAC1 (0.80) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL14254927 | 0.83 | HDAC1 (0.80) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL26961108 | 0.82 | HDAC1 (0.68) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL15424152 | 0.81 | MAPT (0.65) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL26961109 | 0.78 | HDAC1 (0.70) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL15424146 | 0.77 | ALB (0.52) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL30702320 | 0.77 | HDAC1 (0.68) | HDAC3HDAC1HDAC4HDAC2HDAC8 | |
| SCHEMBL26961111 | 0.77 | HDAC3 (0.68) | HDAC3HDAC1HDAC4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661425-B1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | CURIS INC (US) | 2018-02-28 | — | — | EP | disclosed |