Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.75 |
| ▸ | MAPT | P10636 | 5/20 | 0.75 |
| ▸ | GAA | P10253 | 5/20 | 0.75 |
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.75 |
| ▸ | POLB | P06746 | 3/20 | 0.75 |
| ▸ | THRB | P10828 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYB5R3 | P00387 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12297404 | 0.84 | KMT2A (1.00) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL12297412 | 0.84 | KMT2A (0.72) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL12297426 | 0.79 | KMT2A (0.76) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL12297443 | 0.74 | KMT2A (0.64) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL20830150 | 0.74 | KDM4E (0.47) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL20830314 | 0.73 | KMT2A (0.46) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL20830170 | 0.72 | KDM4C (0.51) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL20819200 | 0.72 | KMT2A (0.51) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL20830154 | 0.71 | KMT2A (0.41) | KMT2AMAPTGAAMEN1L3MBTL1 | |
| SCHEMBL19918062 | 0.71 | KDM5A (0.51) | KMT2AMAPTGAAMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367798-B1 | PYRAZOLONE DERIVATIVES USEFUL IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | UNIV NORTHWESTERN (US) | 2018-02-28 | — | — | EP | disclosed |