Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.58 |
| ▸ | JAK2 | O60674 | 4/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.58 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.58 |
| ▸ | JAK3 | P52333 | 6/20 | 0.53 |
| ▸ | INSR | P06213 | 5/20 | 0.52 |
| ▸ | IGF1R | P08069 | 5/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | TXK | P42681 | 1/20 | 0.52 |
| ▸ | BLK | P51451 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19921062 | 0.85 | ALK (0.59) | ALKJAK2SRCTNK2JAK3 | |
| SCHEMBL19921130 | 0.81 | ALK (0.60) | ALKJAK2SRCTNK2JAK3 | |
| SCHEMBL18488408 | 0.77 | ALK (0.89) | ALKJAK2SRCTNK2JAK3 | |
| SCHEMBL11320105 | 0.75 | JAK2 (0.48) | ALKJAK2SRCTNK2EGFR | |
| SCHEMBL24255230 | 0.75 | ALK (0.74) | ALKJAK2SRCTNK2JAK3 | |
| SCHEMBL18194340 | 0.74 | ALK (0.69) | ALKJAK2SRCTNK2JAK3 | |
| SCHEMBL19921192 | 0.74 | LRRK2 (0.58) | ALKJAK2SRCTNK2INSR | |
| SCHEMBL19921170 | 0.74 | EGFR (0.55) | ALKEGFRPTK2 | |
| SCHEMBL18488402 | 0.74 | ALK (1.00) | ALKJAK2SRCTNK2JAK3 | |
| SCHEMBL11296289 | 0.74 | ALK (0.50) | ALKJAK2SRCTNK2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290420-B1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | UNIV XIAMEN (CN) | 2020-12-09 | — | — | EP | claimed |
| EP-3290420-A1 | PYRIMIDINE PYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Xiamen University (CN) | 2018-03-07 | — | — | EP | claimed |