Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 7/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1992988 | 0.88 | TDP1 (0.36) | MAP2K1MAP2K2KITBRAF | |
| SCHEMBL12539792 | 0.85 | MAP2K1 (0.37) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL1981292 | 0.84 | MAP2K1 (0.43) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL1992506 | 0.83 | MAP2K1 (0.36) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL15129697 | 0.83 | IDO1 (0.37) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL2004405 | 0.82 | IDO1 (0.37) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL1978944 | 0.82 | MAP2K1 (0.49) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL12597717 | 0.82 | MAP2K1 (0.40) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL1979721 | 0.80 | MAP2K1 (0.44) | IDO1MAP2K1MAP2K2CHEK1MAPK10 | |
| SCHEMBL2048640 | 0.80 | MAP2K1 (0.32) | IDO1MAP2K1MAP2K2CHEK1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509964-B1 | Heterocyclic sulfonamide derivatives | NOVARTIS AG (CH) | 2014-04-30 | — | — | EP | claimed |
| WO-2011070030-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070030-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-06-16 | — | — | WO | disclosed |