Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
| ▸ | SCN4A | P35499 | 1/20 | 0.69 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261590 | 0.95 | SCN9A (0.91) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3266611 | 0.95 | SCN9A (0.91) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3243928 | 0.92 | SCN9A (0.85) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3246944 | 0.92 | SCN9A (0.85) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL19922255 | 0.92 | SCN9A (1.00) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3248908 | 0.92 | SCN9A (0.85) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3246714 | 0.91 | SCN9A (0.85) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3126802 | 0.90 | SCN9A (1.00) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3130210 | 0.89 | SCN9A (0.85) | SCN9ASCN5AKCNH2SCN4ASCN3A | |
| SCHEMBL3244028 | 0.88 | SCN9A (1.00) | SCN9ASCN5AKCNH2SCN4ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180068053-A1 | SYSTEMS AND METHODS OF SELECTING COMPOUNDS WITH REDUCED RISK OF CARDIOTOXICITY USING CARDIAC SODIUM ION CHANNEL MODELS | UNIV ALBERTA (CA) | 2018-03-08 | — | — | US | disclosed |
| US-20180068053-A1 | SYSTEMS AND METHODS OF SELECTING COMPOUNDS WITH REDUCED RISK OF CARDIOTOXICITY USING CARDIAC SODIUM ION CHANNEL MODELS | UNIV ALBERTA (CA) | 2018-03-08 | — | — | US | disclosed |