Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.30 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19922794 | 0.84 | AR (0.34) | ARKDM4EALDH1A1TP53SMN1; SMN2 | |
| Zagociguat SCHEMBL19922804 | 0.84 | AR (0.34) | ARPDE5APDE4APDE1APDE1B | |
| SCHEMBL19922744 | 0.84 | PDE5A (0.36) | ARPDE5APDE4APDE1APDE1B | |
| Zagociguat SCHEMBL21333483 | 0.83 | PDE5A (0.35) | ARPDE5APDE4APDE1APDE1B | |
| Zagociguat SCHEMBL21332996 | 0.83 | AR (0.34) | ARPDE5APDE4APDE1APDE1B | |
| SCHEMBL19922956 | 0.82 | HDAC6 (0.36) | ARPDE5APDE4APDE1APDE1B | |
| Zagociguat SCHEMBL21332766 | 0.82 | PDE5A (0.34) | ARPDE5APDE4APDE1APDE1B | |
| Zagociguat SCHEMBL21332963 | 0.82 | PDE5A (0.33) | ARPDE5APDE4APDE1APDE1B | |
| Zagociguat SCHEMBL21332705 | 0.81 | PDE5A (0.33) | ARPDE5APDE4APDE1APDE1B | |
| SCHEMBL23875659 | 0.80 | AR (0.34) | ARPDE5APDE4APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326761-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC (US) | 2025-10-23 | — | — | US | disclosed |
| CN-117105939-A | Fused bicyclic sGC stimulators | 帝善多制药公司 | 2023-11-24 | — | — | CN | disclosed |
| US-11731977-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11731977-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-11731977-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| EP-3872080-B1 | FUSED BICYCLIC SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |
| EP-3872080-B1 | FUSED BICYCLIC SGC STIMULATORS | CYCLERION THERAPEUTICS INC (US) | 2023-08-16 | — | — | EP | disclosed |
| CN-109790167-B | SGC stimulators | 塞科里昂医疗股份有限公司 | 2023-06-20 | — | — | CN | disclosed |
| US-20220009937-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2022-01-13 | — | — | US | disclosed |
| US-20220009937-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2022-01-13 | — | — | US | disclosed |
| US-10472363-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-10472363-B2 | SGC stimulators | CYCLERION THERAPEUTICS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20190248794-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2019-08-15 | — | — | US | disclosed |
| US-20190248794-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2019-08-15 | — | — | US | disclosed |
| EP-3507291-A1 | FUSED BICYCLIC SGC STIMULATORS | Cyclerion Therapeutics, Inc. (US) | 2019-07-10 | — | — | EP | disclosed |
| WO-2018045276-A1 | FUSED BICYCLIC SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| WO-2018045276-A1 | FUSED BICYCLIC SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-03-08 | — | — | WO | disclosed |
| US-20180065971-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2018-03-08 | — | — | US | disclosed |
| US-20180065971-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2018-03-08 | — | — | US | disclosed |
| US-20180065971-A1 | sGC STIMULATORS | TISENTO THERAPEUTICS INC. | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472363-B2 | SGC stimulators | GUCY1A2, PRKG1, GMPS | AR 4543/4885PDE5A 12/4885PDE4A 16/4885 |
| US-20250326761-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885PDE5A 12/4885PDE4A 16/4885 |
| US-20180065971-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885PDE5A 12/4885PDE4A 16/4885 |
| US-20220009937-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885PDE5A 12/4885PDE4A 16/4885 |
| US-11731977-B2 | SGC stimulators | GUCY1A2, PRKG1, GMPS | AR 4543/4885PDE5A 12/4885PDE4A 16/4885 |
| US-20190248794-A1 | sGC STIMULATORS | GUCY1A2, PRKG1, GMPS | AR 4543/4885PDE5A 12/4885PDE4A 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.