Sugi Predict

Sugi Predict / Compounds / SCHEMBL19928079

SCHEMBL19928079

SCHEMBL19928079

CN(C)Cc1cccc(OCC(O)CN2CCc3ccc(C4CCCCN(Cc5cccc(OCC(O)CN6CCc7ccccc7C6)c5)C4)cc3C2)c1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 19/20 0.66
▸ WDR77 Q9BQA1 18/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15833641 0.84 PRMT5 (0.72) PRMT5WDR77
SCHEMBL15943770 0.81 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15833642 0.81 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15943803 0.78 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15833648 0.74 PRMT5 (0.73) PRMT5WDR77
SCHEMBL15944171 0.74 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15944161 0.74 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15833652 0.74 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15944079 0.73 PRMT5 (0.81) PRMT5WDR77
SCHEMBL15944160 0.73 PRMT5 (1.00) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9908887-B2 PRMT5 inhibitors and uses thereof Epizyme, Inc. (US) 2018-03-06 — — US disclosed