Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 11/20 | 0.39 |
| ▸ | GSK3B | P49841 | 11/20 | 0.39 |
| ▸ | FLT3 | P36888 | 9/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.39 |
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | PLK1 | P53350 | 6/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.39 |
| ▸ | PRKACA | P17612 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19928495 | 0.87 | GSK3A (0.41) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL19928493 | 0.86 | GSK3A (0.37) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL19928489 | 0.86 | GSK3A (0.37) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL19928490 | 0.84 | GSK3A (0.37) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL18682820 | 0.83 | CDK2 (0.38) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL20235320 | 0.83 | GSK3A (0.38) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL14685259 | 0.83 | GSK3A (0.38) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL21387875 | 0.82 | CDK2 (0.36) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL18682974 | 0.81 | CHUK (0.41) | GSK3AGSK3BFLT3PIK3CGJAK2 | |
| SCHEMBL18682823 | 0.80 | GSK3A (0.40) | GSK3AGSK3BFLT3JAK2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908878-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-03-06 | — | — | US | disclosed |