Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.60 |
| ▸ | NUAK2 | Q9H093 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | BLK | P51451 | 1/20 | 0.59 |
| ▸ | BMX | P51813 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | CTSC | P53634 | 1/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.59 |
| ▸ | BTK | Q06187 | 1/20 | 0.59 |
| ▸ | ITK | Q08881 | 1/20 | 0.59 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.59 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.59 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.59 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10127973 | 0.92 | EGFR (0.72) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL19928475 | 0.88 | EGFR (0.77) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10128148 | 0.85 | EGFR (0.69) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10128071 | 0.83 | EGFR (0.68) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10128043 | 0.81 | EGFR (0.58) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10128143 | 0.81 | EGFR (0.68) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10128048 | 0.80 | EGFR (0.59) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10127950 | 0.80 | EGFR (0.78) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10128034 | 0.79 | EGFR (0.66) | EGFRNUAK1NUAK2PLK4GAK | |
| SCHEMBL10128096 | 0.78 | EGFR (0.54) | EGFRNUAK1NUAK2PLK4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908884-B2 | EGFR inhibitors and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-06 | — | — | US | disclosed |