Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18711179 | 0.97 | PIM1 (0.42) | PIM1PIM2IGF1RPTPN1HPGD | |
| SCHEMBL18711226 | 0.97 | PIM1 (0.42) | PIM1PIM2IGF1RPTPN1HPGD | |
| SCHEMBL19928658 | 0.97 | PIM1 (0.42) | PIM1PIM2IGF1RPTPN1HPGD | |
| SCHEMBL18711174 | 0.97 | PIM1 (0.42) | PIM1PIM2IGF1RPTPN1HPGD | |
| SCHEMBL18711177 | 0.97 | PIM1 (0.42) | PIM1PIM2IGF1RPTPN1HPGD | |
| SCHEMBL18711250 | 0.97 | PIM1 (0.42) | PIM1PIM2IGF1RPTPN1HPGD | |
| SCHEMBL20355919 | 0.85 | POLB (0.37) | GSK3B | |
| SCHEMBL20374334 | 0.84 | POLB (0.36) | HPGD | |
| SCHEMBL20355916 | 0.82 | HPGD (0.47) | PIM1HPGDRAB9ANPC1TDP1 | |
| SCHEMBL20374327 | 0.80 | HPGD (0.45) | PIM1HPGDRAB9ANPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908872-B2 | Methods to treat lymphoplasmacytic lymphoma | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-06 | — | — | US | disclosed |