Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29848774 | 0.80 | BRD4 (0.45) | BRD4ALDH1A1GFERNPC1RAB9A | |
| SCHEMBL16650175 | 0.80 | BRD4 (0.45) | BRD4ALDH1A1GFERNPC1RAB9A | |
| SCHEMBL17702512 | 0.80 | BRD4 (0.37) | BRD4ADORA2AADORA1ADORA3SCN9A | |
| SCHEMBL25042927 | 0.80 | BRD4 (0.37) | BRD4ADORA2AADORA1ADORA3SCN9A | |
| SCHEMBL29848945 | 0.78 | BRD4 (0.57) | BRD4ALDH1A1GFER | |
| SCHEMBL16650148 | 0.78 | BRD4 (0.57) | BRD4ALDH1A1GFER | |
| SCHEMBL19931457 | 0.78 | BACE1 (0.47) | BRD4ADORA2AADORA1ADORA3TLR8 | |
| SCHEMBL21931525 | 0.77 | BRD4 (0.35) | BRD4ADORA2AADORA1ADORA3SCN9A | |
| SCHEMBL25042926 | 0.76 | TLR8 (0.36) | BRD4ADORA2AADORA1ADORA3SCN9A | |
| SCHEMBL17702514 | 0.75 | TLR8 (0.35) | BRD4ADORA2AADORA1ADORA3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4134364-A2 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2023-02-15 | — | — | EP | disclosed |
| EP-3640241-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-04-22 | — | — | EP | disclosed |
| EP-3290407-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc (US) | 2018-03-07 | — | — | EP | disclosed |