Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442061 | 0.90 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL1440658 | 0.90 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL1991566 | 0.89 | BACE1 (0.69) | BACE1BACE2 | |
| SCHEMBL10155190 | 0.80 | BACE1 (0.82) | BACE1BACE2 | |
| SCHEMBL3275857 | 0.80 | BACE1 (0.82) | BACE1BACE2 | |
| SCHEMBL3275862 | 0.80 | BACE1 (0.82) | BACE1BACE2 | |
| SCHEMBL1441003 | 0.80 | BACE1 (0.54) | BACE1BACE2 | |
| SCHEMBL4083365 | 0.80 | BACE1 (0.72) | BACE1 | |
| SCHEMBL4078021 | 0.78 | BACE1 (1.00) | BACE1NPC1RAB9ASMN1; SMN2BACE2 | |
| SCHEMBL12359052 | 0.78 | BACE1 (1.00) | BACE1NPC1RAB9ASMN1; SMN2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2011-06-08 | — | — | EP | claimed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | claimed |
| EP-2328903-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |