⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469266 | 0.72 | CYP19A1 (0.31) | — | |
| SCHEMBL24657646 | 0.70 | — | — | |
| SCHEMBL19403365 | 0.69 | — | — | |
| SCHEMBL21100528 | 0.67 | CHRNA7 (0.32) | — | |
| SCHEMBL24061523 | 0.67 | — | — | |
| SCHEMBL29446318 | 0.66 | MAPK1 (0.33) | — | |
| SCHEMBL19250885 | 0.64 | — | — | |
| SCHEMBL22681333 | 0.64 | — | — | |
| SCHEMBL12569480 | 0.64 | — | — | |
| SCHEMBL24276515 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11130780-B2 | Inhibitors of growth factor activation enzymes | WASHINGTON UNIVERSITY (US) | 2021-09-28 | — | — | US | disclosed |
| US-20180066015-A1 | INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES | WASHINGTON UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |