Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 19/20 | 0.67 |
| ▸ | VEGFA | P15692 | 4/20 | 0.67 |
| ▸ | FLT1 | P17948 | 4/20 | 0.67 |
| ▸ | EGLN3 | Q9H6Z9 | 6/20 | 0.49 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.47 |
| ▸ | TET3 | O43151 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.47 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.42 |
| ▸ | KDM6B | O15054 | 2/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19933445 | 0.82 | EGLN1 (0.59) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL1921504 | 0.81 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL19933512 | 0.81 | EGLN1 (0.65) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL19933528 | 0.80 | EGLN1 (0.68) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL3139000 | 0.75 | EGLN1 (0.85) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL968220 | 0.74 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL31028951 | 0.74 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL705432 | 0.74 | EGLN1 (0.56) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL19933462 | 0.74 | EGLN1 (0.76) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL12900998 | 0.73 | EGLN1 (0.57) | EGLN1VEGFAFLT1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180065933-A1 | DEUTERIUM-ENRICHED HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE ENZYME INHIBITORS | AKEBIA THERAPEUTICS, INC. (US) | 2018-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065933-A1 | DEUTERIUM-ENRICHED HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE ENZYME INHIBITORS | HIF1AN, EGLN3, EGLN2 | EGLN1 6/4885VEGFA 286/4885FLT1 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.