Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.40 |
| ▸ | JAK3 | P52333 | 9/20 | 0.40 |
| ▸ | JAK1 | P23458 | 8/20 | 0.40 |
| ▸ | EIF2AK4 | Q9P2K8 | 8/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994799 | 0.91 | EIF2AK4 (0.41) | JAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1996538 | 0.81 | EIF2AK4 (0.42) | JAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL2031299 | 0.80 | JAK3 (0.47) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL2034967 | 0.78 | JAK3 (0.43) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL1993982 | 0.76 | EIF2AK4 (0.43) | JAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1992253 | 0.75 | EIF2AK4 (0.42) | JAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL1994795 | 0.75 | EIF2AK4 (0.42) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL1997370 | 0.75 | EIF2AK4 (0.42) | JAK2JAK3JAK1EIF2AK4ADORA2A | |
| SCHEMBL15194120 | 0.74 | EIF2AK4 (0.43) | JAK2JAK3JAK1EIF2AK4 | |
| SCHEMBL15194122 | 0.74 | EIF2AK4 (0.43) | JAK2JAK3JAK1EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |