Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 11/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | TPO | P07202 | 1/20 | 0.44 |
| ▸ | EPX | P11678 | 1/20 | 0.44 |
| ▸ | LPO | P22079 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1956091 | 0.85 | CDK8 (0.49) | CDK8MPOTPOEPXLPO | |
| SCHEMBL31180981 | 0.82 | KMT2A (0.53) | CDK8MPOTPOEPXLPO | |
| SCHEMBL26647783 | 0.80 | KDM4E (0.48) | NR4A2ALKKMT2ACYP1A2CYP3A4 | |
| SCHEMBL29398024 | 0.79 | BCL2 (0.49) | CDK8NR4A2ALK | |
| SCHEMBL19341716 | 0.79 | BCL2 (0.49) | CDK8NR4A2ALK | |
| SCHEMBL19513720 | 0.79 | NCEH1 (0.47) | HSD17B10NR4A2HTTKMT2ACYP1A2 | |
| SCHEMBL1957491 | 0.79 | HSD17B10 (0.59) | HSD17B10NR4A2TSHRKMT2ACYP1A2 | |
| SCHEMBL12765104 | 0.78 | CCNC (0.48) | CDK8NR4A2KMT2AL3MBTL1 | |
| SCHEMBL1958013 | 0.78 | HSD17B10 (0.48) | HSD17B10NR4A2HTTTSHRKMT2A | |
| SCHEMBL31181094 | 0.75 | CDK8 (0.49) | CDK8MPOTPOEPXLPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641897-B | Bcl-2 selective inhibitors, their preparation and use | 北京赛林泰医药技术有限公司 | 2021-12-07 | — | — | CN | disclosed |
| WO-2018041248-A1 | BCL-2 SELECTIVE INHIBITOR AND PREPARATION AND USE THEREOF | 北京赛林泰医药技术有限公司 | 2018-03-08 | — | — | WO | disclosed |