Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 15/20 | 0.98 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.90 |
| ▸ | SGPL1 | O95470 | 7/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19940770 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL19940773 | 0.98 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL19941226 | 0.95 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL12000662 | 0.89 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL12000663 | 0.89 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL12000661 | 0.89 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL1814909 | 0.89 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL19940771 | 0.88 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL19941212 | 0.88 | S1PR1 (1.00) | S1PR1S1PR3SGPL1 | |
| SCHEMBL19941215 | 0.88 | S1PR1 (0.95) | S1PR1S1PR3SGPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190218193-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-07-18 | — | — | US | claimed |
| EP-3507278-B1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2021-01-27 | — | — | EP | disclosed |
| US-10633354-B2 | Substituted tricyclic heterocyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-04-28 | — | — | US | disclosed |
| US-10633354-B2 | Substituted tricyclic heterocyclic compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190218193-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-07-18 | — | — | US | disclosed |
| US-20190218193-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2019-07-18 | — | — | US | disclosed |
| WO-2018045149-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633354-B2 | Substituted tricyclic heterocyclic compounds | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR3 2/4885SGPL1 61/4885 |
| US-20190218193-A1 | SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR3 2/4885SGPL1 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.