Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 14/20 | 0.55 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.49 |
| ▸ | PNP | P00491 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.44 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19945293 | 0.88 | TLR7 (0.59) | TLR7NSD2NSD3PNPTLR8 | |
| SCHEMBL19945800 | 0.87 | TLR7 (0.60) | TLR7NSD2NSD3PNPTLR8 | |
| SCHEMBL19924997 | 0.81 | TLR7 (0.63) | TLR7TLR8NUDT1 | |
| SCHEMBL19924616 | 0.75 | TLR7 (0.62) | TLR7TLR8 | |
| SCHEMBL21253066 | 0.75 | TLR7 (0.77) | TLR7TLR8 | |
| SCHEMBL19924629 | 0.74 | TLR7 (0.86) | TLR7TLR8 | |
| SCHEMBL18207460 | 0.73 | TLR7 (0.63) | TLR7TLR8 | |
| SCHEMBL19924970 | 0.73 | TLR7 (0.60) | TLR7TLR8 | |
| SCHEMBL18207373 | 0.73 | TLR7 (0.62) | TLR7TLR8 | |
| SCHEMBL29099416 | 0.73 | TLR7 (0.64) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018041763-A1 | 7-SUBSTITUTED SULFONIMIDOYLPURINONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-08 | — | — | WO | disclosed |