Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 12/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15198112 | 1.00 | EIF2AK4 (0.46) | EIF2AK4IGF1RHDAC4HDAC6DGAT2 | |
| SCHEMBL1995230 | 0.92 | EIF2AK4 (0.44) | EIF2AK4HDAC4HDAC6USP30 | |
| SCHEMBL1995228 | 0.92 | EIF2AK4 (0.44) | EIF2AK4HDAC4HDAC6USP30 | |
| SCHEMBL1993982 | 0.92 | EIF2AK4 (0.43) | EIF2AK4HDAC4HDAC6USP30 | |
| SCHEMBL15193621 | 0.91 | EIF2AK4 (0.44) | EIF2AK4HDAC4HDAC6USP30ALOX5 | |
| SCHEMBL15193620 | 0.91 | EIF2AK4 (0.44) | EIF2AK4HDAC4HDAC6USP30ALOX5 | |
| SCHEMBL2053807 | 0.90 | EIF2AK4 (0.42) | EIF2AK4HDAC4HDAC6USP30 | |
| SCHEMBL15193373 | 0.90 | EIF2AK4 (0.42) | EIF2AK4IGF1RHDAC4HDAC6USP30 | |
| SCHEMBL15193374 | 0.90 | EIF2AK4 (0.42) | EIF2AK4IGF1RHDAC4HDAC6USP30 | |
| SCHEMBL15193920 | 0.90 | EIF2AK4 (0.42) | EIF2AK4HDAC4HDAC6USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338888-A1 | Imidazopyridine derivatives as JAK inhibitors | Almirall, S.A. (ES) | 2011-06-29 | — | — | EP | disclosed |