Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 9/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28903809 | 0.90 | MELK (0.70) | MELKPRKD1MAP4K1 | |
| SCHEMBL19951632 | 0.89 | MELK (0.59) | MELKPRKD1MAP4K1 | |
| SCHEMBL28903756 | 0.86 | MELK (0.64) | MELKPRKD1MAP4K1 | |
| SCHEMBL28903817 | 0.85 | MELK (0.63) | MELKPRKD1MAP4K1 | |
| SCHEMBL28903759 | 0.83 | MAP4K1 (0.64) | MELKPRKD1MAP4K1 | |
| SCHEMBL19951688 | 0.82 | MELK (0.72) | MELKPRKD1MAP4K1 | |
| SCHEMBL28965179 | 0.81 | MELK (0.66) | MELKPRKD1MAP4K1 | |
| SCHEMBL28960285 | 0.81 | MELK (0.57) | MELKPRKD1MAP4K1 | |
| SCHEMBL28903771 | 0.80 | MELK (0.71) | MELKPRKD1MAP4K1 | |
| SCHEMBL28977189 | 0.79 | MELK (0.73) | MELKPRKD1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115819417-A | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-109923114-B | Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer | 因赛特公司 | 2022-11-01 | — | — | CN | disclosed |
| EP-3510032-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | Incyte Corporation (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049200-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |