Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.68 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.68 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | CCKBR | P32239 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2392374 | 0.82 | KCNN4 (0.69) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL28044107 | 0.81 | KCNN4 (0.68) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL29499525 | 0.81 | KCNN4 (1.00) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL41130 | 0.81 | KCNN4 (1.00) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL2392101 | 0.81 | KCNN4 (0.72) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL23995584 | 0.81 | KCNN4 (0.68) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL2338372 | 0.81 | KCNN4 (0.72) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL1750941 | 0.80 | KCNN4 (0.58) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL29008837 | 0.77 | KCNN4 (0.62) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 | |
| SCHEMBL29008831 | 0.74 | KCNN4 (0.58) | KCNN4KCNA3CYP11B1CYP11B2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049214-A9 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-10-18 | — | — | WO | disclosed |
| WO-2018049214-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |