Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1989715 | 0.90 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGDHODH | |
| SCHEMBL1990422 | 0.86 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL12564700 | 0.86 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL9959801 | 0.83 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL1995280 | 0.78 | CYP3A4 (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL1992065 | 0.78 | KDM4E (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGKDM4E | |
| SCHEMBL1992273 | 0.77 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL1990243 | 0.77 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL1990247 | 0.77 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL12564694 | 0.77 | PIK3CD (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633313-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-20110152296-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152296-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, BCL9, MALT1 | PIK3CD 16/4885PIK3CA 26/4885PIK3CB 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.