Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.66 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.66 |
| ▸ | PARP14 | Q460N5 | 10/20 | 0.56 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.55 |
| ▸ | TNKS | O95271 | 2/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20355545 | 0.90 | PARP1 (0.71) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL6646629 | 0.86 | PARP1 (0.59) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL6646176 | 0.85 | PARP1 (0.62) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL6647290 | 0.85 | PARP1 (0.58) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL6646129 | 0.84 | PARP1 (0.60) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL17298080 | 0.84 | PARP1 (0.66) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL6644094 | 0.84 | PARP1 (0.63) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL31483741 | 0.83 | PARP1 (0.69) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL21072527 | 0.83 | PARP1 (0.69) | PARP1PARP2PARP14PARP11PDE10A | |
| SCHEMBL19331353 | 0.82 | PARP2 (0.54) | PARP1PARP2PARP14PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018046933-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2018-03-15 | — | — | WO | disclosed |