Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27189680 | 0.84 | SMN1; SMN2 (0.40) | HPGDALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4463232 | 0.84 | KDM4E (0.46) | GAAHPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL29665109 | 0.82 | ABL1 (0.46) | GAAHPGDALDH1A1SMN1; SMN2ABL1 | |
| SCHEMBL27433079 | 0.81 | MYC (0.44) | GAAHPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8135257 | 0.81 | GAA (0.46) | GAAHPGDALDH1A1SMN1; SMN2ABL1 | |
| SCHEMBL23537740 | 0.79 | ABL1 (0.56) | GAAHPGDALDH1A1SMN1; SMN2ABL1 | |
| SCHEMBL23834841 | 0.79 | KDM4E (0.42) | GAAHPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL523584 | 0.79 | ABL1 (0.57) | GAAHPGDALDH1A1SMN1; SMN2ABL1 | |
| SCHEMBL14747755 | 0.78 | KDM4E (0.41) | GAAHPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL23169066 | 0.78 | ABL1 (0.42) | GAAHPGDALDH1A1SMN1; SMN2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018046684-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 5-{[2-(ALKOXYMETHYL)-3,3,3-TRIFLUORO-2-HYDROXY-1-PHENYLPROPYL]AMINO}QUINOLIN-2(1H)-ONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-03-15 | — | — | WO | disclosed |
| WO-2018046684-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 5-{[2-(ALKOXYMETHYL)-3,3,3-TRIFLUORO-2-HYDROXY-1-PHENYLPROPYL]AMINO}QUINOLIN-2(1H)-ONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-03-15 | — | — | WO | disclosed |