Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.87 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.72 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL630399 | 0.93 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL2031098 | 0.92 | PARP1 (0.88) | PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL5620758 | 0.89 | PARP1 (0.86) | PARP1PARP2AURKAAURKB | |
| SCHEMBL5621649 | 0.87 | PARP1 (0.86) | PARP1PARP2 | |
| SCHEMBL630104 | 0.85 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL423949 | 0.83 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL630352 | 0.83 | PARP1 (0.74) | PARP1PARP2 | |
| SCHEMBL5621048 | 0.83 | PARP1 (0.88) | PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL18614331 | 0.82 | PARP1 (0.86) | PARP1PARP2 | |
| SCHEMBL630591 | 0.82 | PARP1 (0.72) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2338487-B1 | Combination therapy with PARP inhibitors | ABBOTT LAB (US) | 2013-09-11 | — | — | EP | disclosed |
| EP-1869011-B1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH A QUATERNARY CARBON AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LAB (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2338487-A1 | Combination therapy with PARP inhibitors | Abbott Laboratories (US) | 2011-06-29 | — | — | EP | disclosed |