Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 18/20 | 0.75 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.75 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.75 |
| ▸ | ITGA5 | P08648 | 8/20 | 0.75 |
| ▸ | ITGB6 | P18564 | 9/20 | 0.61 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.57 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.55 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953686 | 1.00 | ITGAV (0.75) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20024858 | 0.90 | ITGAV (0.92) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20025135 | 0.90 | ITGAV (0.92) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4245277 | 0.86 | ITGAV (0.85) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4241327 | 0.86 | ITGAV (1.00) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL19953591 | 0.85 | ITGAV (0.55) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20024902 | 0.83 | ITGAV (0.80) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL21812287 | 0.83 | ITGAV (0.80) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL20025167 | 0.83 | ITGAV (0.80) | ITGAVITGB3ITGB1ITGA5ITGB6 | |
| SCHEMBL4245157 | 0.82 | ITGB1 (0.90) | ITGAVITGB3ITGB1ITGA5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3509590-A1 | N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE | Pliant Therapeutics, Inc. (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049068-A1 | N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE | PLIANT THERAPEUTICS, INC. (US) | 2018-03-15 | — | — | WO | disclosed |