Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11122522 | 0.87 | MAPK1 (0.56) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL11119052 | 0.87 | MAPK1 (0.56) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL11118846 | 0.87 | MAPK1 (0.56) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL11118159 | 0.87 | MAPK1 (0.56) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL19091174 | 0.86 | POLB (0.66) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL170949 | 0.86 | POLB (0.66) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL172673 | 0.86 | POLB (0.66) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL20646161 | 0.82 | SMN1; SMN2 (0.45) | POLBMAPK1KMT2ATSHRKDM4E | |
| SCHEMBL13257871 | 0.82 | POLB (0.66) | POLBMAPK1KMT2AMEN1TSHR | |
| SCHEMBL13133346 | 0.82 | POLB (0.66) | POLBMAPK1KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |