Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17472840 | 0.90 | EGLN1 (0.53) | EGLN1XDH | |
| SCHEMBL19955399 | 0.86 | EGLN1 (0.52) | EGLN1XDH | |
| SCHEMBL19955382 | 0.86 | EGLN1 (0.52) | EGLN1CHEK2MAP4K4PRKAA1XDH | |
| SCHEMBL19955360 | 0.84 | EGLN1 (0.48) | EGLN1CHEK2SCN9A | |
| SCHEMBL19955354 | 0.84 | EGLN1 (0.41) | EGLN1XDHSCN9A | |
| SCHEMBL19955392 | 0.83 | KDM1A (0.40) | EGLN1CYP11B2GRM2 | |
| SCHEMBL19955396 | 0.83 | PARP10 (0.42) | EGLN1XDHSCN9A | |
| SCHEMBL19955346 | 0.83 | EGLN1 (0.42) | EGLN1KDR | |
| SCHEMBL19955387 | 0.81 | EGLN1 (0.43) | EGLN1XDH | |
| SCHEMBL19955413 | 0.81 | EGLN1 (0.43) | EGLN1MAP4K2XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2980085-B1 | PYRAZOLE DERIVATIVE | TEIJIN PHARMA LTD (JP) | 2018-03-14 | — | — | EP | disclosed |