Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLR1 | P15328 | 11/20 | 0.49 |
| ▸ | FOLR2 | P14207 | 8/20 | 0.49 |
| ▸ | GART | P22102 | 10/20 | 0.46 |
| ▸ | SLC46A1 | Q96NT5 | 6/20 | 0.46 |
| ▸ | SLC19A1 | P41440 | 3/20 | 0.46 |
| ▸ | DHFR | P00374 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3161406 | 0.83 | FOLR1 (0.69) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL3161383 | 0.83 | FOLR1 (0.69) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL3156341 | 0.79 | FOLR1 (0.54) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL3156359 | 0.77 | FOLR1 (0.57) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL18551757 | 0.74 | GART (0.65) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL2358592 | 0.73 | FOLR1 (0.51) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL19956093 | 0.73 | FOLR1 (0.57) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL28021410 | 0.71 | FOLR1 (0.56) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL28937841 | 0.69 | FOLR1 (0.53) | FOLR1FOLR2GARTSLC46A1SLC19A1 | |
| SCHEMBL17598267 | 0.69 | FOLR1 (0.84) | FOLR1FOLR2GARTSLC46A1SLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2995199-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2018-03-14 | — | — | EP | disclosed |