Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.65 |
| ▸ | CTSD | P07339 | 5/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.62 |
| ▸ | CTSE | P14091 | 1/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274085 | 0.87 | BACE1 (0.65) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL3279074 | 0.87 | BACE1 (0.68) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL15509971 | 0.87 | BACE1 (0.73) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL2526504 | 0.87 | BACE1 (0.73) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL1990663 | 0.86 | BACE1 (0.72) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL1990659 | 0.86 | BACE1 (0.72) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL15509497 | 0.83 | BACE1 (0.73) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL15509822 | 0.83 | BACE1 (0.68) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL1993419 | 0.83 | BACE1 (0.70) | BACE1CTSDKCNH2CTSEBACE2 | |
| SCHEMBL1993421 | 0.83 | BACE1 (0.70) | BACE1CTSDKCNH2CTSEBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2328903-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2011-06-08 | — | — | EP | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |