Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 11/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.56 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.56 |
| ▸ | STK10 | O94804 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | BCR | P11274 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.56 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.56 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.56 |
| ▸ | ERN1 | O75460 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20927274 | 0.95 | RET (0.55) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL19956929 | 0.90 | RET (0.58) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL19957404 | 0.88 | KDR (0.57) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL20927401 | 0.88 | KDR (0.57) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL19957121 | 0.87 | KDR (0.61) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL19956972 | 0.83 | KDR (0.60) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL19956959 | 0.82 | KDR (0.62) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL19957028 | 0.81 | RET (0.58) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL20927281 | 0.81 | KDR (0.64) | RETKDRAURKBPDGFRBKIT | |
| SCHEMBL19957034 | 0.81 | KDR (0.60) | RETKDRAURKBPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3293177-A1 | TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-14 | — | — | EP | disclosed |