Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.51 |
| ▸ | AR | P10275 | 6/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21795290 | 0.93 | TLR8 (0.54) | TLR8TLR9TLR7ARKDM4E | |
| SCHEMBL17840412 | 0.87 | TLR8 (0.65) | TLR8TLR9TLR7AR | |
| SCHEMBL17840411 | 0.87 | TLR8 (0.65) | TLR8TLR9TLR7AR | |
| SCHEMBL21661053 | 0.85 | TLR9 (0.53) | TLR8TLR9TLR7ARLRRK2 | |
| SCHEMBL4876295 | 0.84 | AR (0.63) | TLR8TLR9TLR7ARKDM4E | |
| SCHEMBL30317631 | 0.82 | MAPT (0.44) | TLR7KDM4ENPC1ALDH1A1GAA | |
| SCHEMBL26351021 | 0.82 | TLR8 (0.62) | TLR8TLR9TLR7ARKCNMA1 | |
| SCHEMBL23415867 | 0.81 | TLR9 (0.63) | TLR8TLR9TLR7AR | |
| SCHEMBL21795382 | 0.81 | TLR8 (0.54) | TLR8TLR9TLR7ARKDM4E | |
| SCHEMBL21795300 | 0.81 | TLR8 (0.52) | TLR8TLR9TLR7ARKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057948-B1 | SELECTIVELY SUBSTITUTED QUINOLINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2018-03-14 | — | — | EP | disclosed |