Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 18/20 | 0.75 |
| ▸ | WDR77 | Q9BQA1 | 15/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17300967 | 0.86 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL19957534 | 0.85 | PRMT5 (0.75) | PRMT5WDR77USP2 | |
| SCHEMBL19957684 | 0.85 | PRMT5 (0.75) | PRMT5WDR77USP2 | |
| SCHEMBL19957778 | 0.83 | PRMT5 (0.79) | PRMT5WDR77 | |
| SCHEMBL19957545 | 0.82 | PRMT5 (0.57) | PRMT5WDR77USP2 | |
| SCHEMBL19957667 | 0.81 | PRMT5 (0.66) | PRMT5WDR77 | |
| SCHEMBL19957678 | 0.81 | PRMT5 (0.74) | PRMT5WDR77USP2 | |
| SCHEMBL19957543 | 0.81 | PRMT5 (0.54) | PRMT5WDR77 | |
| SCHEMBL19957763 | 0.79 | PRMT5 (0.52) | PRMT5WDR77 | |
| SCHEMBL19957630 | 0.78 | PRMT5 (0.74) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |