Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 19/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19957636 | 0.93 | PRMT5 (0.57) | PRMT5WDR77DRD2HTR2A | |
| SCHEMBL19957659 | 0.91 | PRMT5 (0.51) | PRMT5WDR77DRD2HTR2A | |
| SCHEMBL19957550 | 0.90 | PRMT5 (0.50) | PRMT5WDR77DRD2HTR2A | |
| SCHEMBL19957938 | 0.89 | PRMT5 (0.49) | PRMT5WDR77DRD2HTR2A | |
| SCHEMBL19957757 | 0.87 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL17300964 | 0.86 | PRMT5 (0.77) | PRMT5WDR77 | |
| SCHEMBL17301012 | 0.83 | PRMT5 (0.59) | PRMT5WDR77 | |
| SCHEMBL17300988 | 0.80 | PRMT5 (0.78) | PRMT5WDR77 | |
| SCHEMBL19957605 | 0.80 | PRMT5 (0.72) | PRMT5WDR77DRD2HTR2A | |
| SCHEMBL17301005 | 0.79 | PRMT5 (0.64) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |